The Canadian Aortopathy and Connective Tissue Disorders Registry (CAN-ACT) is a national database established to advance the understanding of heritable syndromic aortopathies in the population across Canada. These rare conditions are often underrepresented in literature and underrecognized among healthcare professionals. CAN-ACT’s mission is to improve awareness, early identification, and treatment of these disorders while informing advocacy efforts to enhance access to specialized care.